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19 September 2018

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Impact Testing for Novel Nasal Drug Delivery Device

Seattle-based biotechnology company, Impel Neuropharma, is developing intranasal drug treatments for central nervous system (CNS) disorders.

Traditional methods for delivering compounds to the CNS are typically invasive. For example a pump implanted in the skull.

Impel Neuropharma aims to develop efficient devices that can send treatments to the upper nasal cavity for direct nose-to-brain delivery.

Nasal drug delivery device

As part of their research they used impaction force testing to compare several nozzle/dose chamber configurations in their nasal drug delivery system.

The impaction force measurements were carried out on Mettler Toledo XS 64 with data output at 10 samples per second. The Mettler Toledo was coupled to an Apple MacBook Pro via an RS232-to-USB cable. They used Windmill Logger software in a Windows Vista virtual machine environment for data acquisition. Data collected by Logger was imported directly into Microsoft Excel for graphical processing and analysis.

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